Risks of the Study

Aphaeresis Donation Risks

Aphaeresis donations are generally very safe, and side effects are rare. Pain and bruising may occur at the needle placement sites. Very rarely, following any procedure, there may be temporary or permanent nerve damage or infection at the needle placement sites. Donors may also develop numbness and tingling around their mouths and fingertips. This effect is associated with the citrate anticoagulant, which binds up calcium to prevent clotting. This effect is temporary and can be lessened or prevented by taking a calcium supplement prior or during the donation. Some donors feel a slight chill during donation because the blood is cooler when it is returned. As with whole blood collections, temporary lowering of the blood pressure may develop, and lightheadedness, dizziness, fainting, and even seizures may occur. However, because the aphaeresis procedure removes only the leukocytes from your blood and returns the other components (red blood cells, platelets, and plasma), possible side effects experienced during whole blood donations (such as lightheadedness) are minimized.

Women Who Can Get Pregnant Or Are Breast Feeding

You may not take part in this study if you are breastfeeding, are pregnant, think that you may be pregnant, or are trying to get pregnant. If you are pregnant or breastfeeding, there may be risks to you and the baby that are not known at this time.

Unknown Risks

You might have side effects or discomforts that are not listed in this form. Some side effects may not be known yet. New ones could happen to you. Tell the study staff right away if you have any problems.