MIMIC® System Detects Immune Response to Nanoparticles

The MIMIC® System was treated with equal doses of titania of various sizes and harvested for analysis on day 3 and day 7. Pokeweed mitogen (PWM) was used as positive control and phosphate buffered saline for the negative control. The immune response increases as particle size decreases. Micron sized titanium dioxide shows minimal response. Data are based 20 donors, excluding the micron-sized titania group (n=5).